5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide

Product Name: 5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide
CAS No.: 868273-06-7
Chemical Name: 5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide
Synonyms: CS-412;Org 27569;ORG 27569;ORG-27569;Org27569 Cannabinoid CB1 receptor allosteric modulator Org-27569;Org27569,Inhibitor,Org-27569,Cannabinoid Receptor,Org 27569,inhibit;N-(4-(piperidin-1-yl)phenethyl)-5-chloro-3-ethyl-1H-indole-2-carboxamide;5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide;5-Chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl-1H-indole-2-carboxamide;1H-Indole-2-carboxamide,5-chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl]-;Org27569 5-Chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl-1H -indole-2-carboxamide
CBNumber: CB42092872
Molecular Formula: C24H28ClN3O
Formula Weight: 409.95
MOL File: 868273-06-7.mol

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5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide Property

Boiling point:: 660.3±55.0 °C(Predicted)
Density: 1.218±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: H2O: <2mg/mL
pka: 14.87±0.30(Predicted)
form: powder
color: white

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2957
Product name: Org 27569
Purity: ≥99%(HPLC)
Packaging: 10
Price: $191
Updated: 2021/12/16

Tocris

Product number: 2957
Product name: Org 27569
Purity: ≥99%(HPLC)
Packaging: 50
Price: $802
Updated: 2021/12/16

Usbiological

Product number: 256120
Product name: Org 27569
Packaging: 10mg
Price: $438
Updated: 2021/12/16

TRC

Product number: O674975
Product name: Org 27569
Packaging: 50mg
Price: $1045
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181073
Product name: Org 27569
Purity: >98%
Packaging: 250mg
Price: $1654.1
Updated: 2021/12/16

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5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide Chemical Properties,Usage,Production

Uses

Org 27569 is a drug that is a used in biological studies for structure-activity relationships of indole-carboxamides as CB1 receptor allosteric modulators.

Biological Activity

Potent CB 1 receptor allosteric modulator (pEC 50 = 8.24). Significantly increases binding of the CB 1 agonist [ 3 H]CP 55.940 (pK b = 5.67) and decreases binding of the CB 1 inverse agonist [ 3 H]SR 141716A (pK b = 5.95). Inhibits CB 1 receptor antagonist efficacy in vitro (pK b = 7.57).

storage

Store at RT

References

[1] price mr1, baillie gl, thomas a, stevenson la, easson m, goodwin r, mclean a, mcintosh l, goodwin g, walker g, westwood p, marrs j, thomson f, cowley p, christopoulos a, pertwee rg, ross ra. allosteric modulation of the cannabinoid cb1 receptor. mol pharmacol. 2005 nov;68(5):1484-95. epub 2005 aug 19.
[2] fay jf1, farrens dl. a key agonist-induced conformational change in the cannabinoid receptor cb1 is blocked by the allosteric ligand org 27569. j biol chem. 2012 sep 28;287(40):33873-82. epub 2012 jul 30.

5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide Preparation Products And Raw materials

Raw materials

Preparation Products

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5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide Suppliers

China 57 Switzerland 1 United Kingdom 2 United States 14 Global 74

Target molecule Corp.

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Alchem Pharmtech,Inc.

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Aladdin Scientific

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View Lastest Price from 5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide manufacturers

Career Henan Chemical Co

Product: 5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide 868273-06-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kgs
Release date: 2020-02-18

868273-06-7, 5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amideRelated Search:

N-Ethylacetamide 2-Aminoethyl(ethyl)amine N-Ethyl-3-methylaniline N-ethyl-pyrrolidone N-(2-Hydroxyethyl)-2-pyrrolidone Org 27569

5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide

Org 27569

Org27569 5-Chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl-1H -indole-2-carboxamide

5-Chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl-1H-indole-2-carboxamide

1H-Indole-2-carboxamide,5-chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl]-

CS-412

5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide

N-(4-(piperidin-1-yl)phenethyl)-5-chloro-3-ethyl-1H-indole-2-carboxamide

ORG 27569;ORG-27569

5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide USP/EP/BP

Org27569 Cannabinoid CB1 receptor allosteric modulator Org-27569

Org27569,Inhibitor,Org-27569,Cannabinoid Receptor,Org 27569,inhibit

868273-06-7

Inhibitors